Original Research Article
Year: 2017 | Month: April | Volume: 7 | Issue: 4 | Pages: 138-143
The Relationship between Serum Lipid Profile and Sebum Secretion in Seborrheic Dermatitis Patients
Theresia L. Toruan1, Nopriyati1, Theodorus2, Yuri Methana Sari3
1Department of Dermatology and Venereology, Dr. Mohammad Hoesin General Hospital, Sriwijaya University
2Medical Research Unit, Sriwijaya University
3Fellow of Department of Dermatology and Venereology, Dr. Mohammad Hoesin General Hospital
Corresponding Author: Theresia L. Toruan
Background: Pathogenesis of seborrheic dermatitis (SD) is not fully elucidated, but this dermatosis is commonly linked with Malassezia spp, skin surface lipids film, sebaceous gland activity, and seborrhea. Sebum lipids are essential proinflammatory factors to provide permissive conditions for SD development. Malassezia spp contain lipases that hydrolyze triglycerides sebum, freeing specific saturated fatty acids that requires to proliferate. The influence of serum lipid on the sebum synthesis is still controversial and the study is ongoing.
Objective: To determine the relationship between serum lipid profile and sebum secretion in seborrheic dermatitis.
Methods: Case series study was conducted from 1st May to 30th June 2016 at Clinic of Dermatology and Venereology Department, Dr. Mohammad Hoesin General Hospital Palembang. Correlation between variables were analyzed by Pearson correlation coefficient test; p<0,05 was considered significant statistically. Statistical analyses were performed using SPSS software (version 17,0).
Results: A total of 30 SD outpatients fulfilled the inclusion criteria and no drop out. This study revealed that majority of sample were female (67,77%) and followed by males (33,3%).This study showed strongly correlation significantly between serum total-cholesterol levels and sebum secretion (r = 0,860; p = 0,000); strongly correlation significantly between serum LDL-cholesterol serum levels and sebum secretion (r = 0,929; p = 0,000); moderately correlation significantly between serum triglyceride levels and sebum secretion (r = 0,445; p = 0,014); and slightly correlation not significant between serum HDL-cholesterol levels and sebum secretion (r = -0,283; p = 0,129).
Conclusions: It can be concluded that there was strongly correlation between serum total-cholesterol as well as LDL-cholesterol levels and sebum secretion in SD patients.
Key words: seborrheic dermatitis, lipid profile, sebum secretion, case series.