Original Research Article
Year: 2017 | Month: April | Volume: 7 | Issue: 4 | Pages: 119-126
Candida Parapsilosis: An Emerging Pathogen, Its Distribution and Antifungal Susceptibility to Fluconazole and Amphotericin B
Shashir Wanjare, Swati Vijay, Preeti Mehta
Department of Microbiology, Seth G.S. Medical College and KEM Hospital, Mumbai
Corresponding Author: Shashir Wanjare
ABSTRACT
Candida is one of the leading causes of fungal infections mainly in immunocompromised patients. Candida parapsilosis infection has been on rise from past few years. Though C. parapsilosis usually susceptible to fluconazole, recent repot suggest resistance. In view of this, a study was carried to know the distribution and antifungal susceptibility of C. parapsilosis to Fluconazole and Amphotericin B. Out of 293 candida species isolated, 43(14.7%) were C. parapsilosis. It accounts for 30(20.8%) cases of Candidemia followed by other infections. Vascular catheterization, Use of antibiotics is common associated risk factors and majority of C. parapsilosis were isolated from Intensive Care unit (ICU). In our study, all isolates were sensitive to Amphotericin B. 39.5% isolates of C. parapsilosis were resistant and 23.3% were susceptible dose dependent to Fluconazole as per latest CLSI 2012 M27-S4 document.
Key words: Candida parapsilosis, antifungal susceptibility.