Year: 2017 | Month: March | Volume: 7 | Issue: 3 | Pages: 351-360
The Effect of Alcohol Consumption on Liver Enzymes, High Density Lipoprotein Cholesterol and Genetic Aspects
Department of Biochemistry, Punjab Medical Sciences, Jalandhar, Punjab, India
Background: Health problems related to life-style and behavior are increasingly common in modern societies. Chronic alcoholism and its related disorder are one of the major problems in the world. Chronic alcohol abuse will cause the drinker to lose control of his or her drinking. the social problems arising from alcoholism are serious and caused by the pathological changes in the brain as well as psychiatric disorder are common in alcoholic with as many as 25 percent suffering from severe psychiatric disturbances. Prolonged alcohol consumptions affect the liver enzymes such as Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline phosphatase (ALP) and Gamma Gutamyltransferase (GGT). In this study we found that genetic polymorphism of the patatin like phospholipase-3 I148M variant (rs738409 C>G)encoding for an isoleucine to methionine substitution, a gene coding for a transmembrane protein most prominently expressed in the hepatocytes due to excessive alcohol consumption. The effect of alcohol consumption on lipoprotein in cholesterol transport as well as novel effects of lipoproteins on vascular cell wall, comprise a complex mechanism through which alcohol is cardioprotective.
Aim: To recognize which factors affect of alcohol consumption on liver enzymes, High density lipoprotein cholesterol and genetic aspects, in this light of current knowledge on this matter.
Methods: We performed a structured literature review identifying studies focusing on the effect of alcohol consumption on the liver enzymes, HDL-Cholesterol and other factors.
Results: In addition to the prolonged alcohol intake and alcohol consumption patterns, such as gender, genetic background, oxidative stress, metabolism abnormalities play a key role in the effect of liver enzymes, HDL- cholesterol and genetic aspects as well as health related disorder.
Conclusions: Understanding the risk factors of excessive alcohol consumption on liver and liver enzymes and high density lipoprotein cholesterol. Moderate alcohol intake is beneficial for heart related problems. Excessive alcohol consumption can adversely affect every organ in the body. There is evidence that chronic consumption increase the risk of upper respiratory and upper digestive tract malignancies and breast cancer.
Key words: Alcohol consumption, Liver enzymes, High density lipoprotein cholesterol, HDL-Cholesterol, Genetic aspect.