Original Research Article
Year: 2017 | Month: March | Volume: 7 | Issue: 3 | Pages: 174-180
Salivary Alpha Defensin 1-3, Total Protein and Total Antioxidant in Children with Gingivitis
Wahdan M. El-kwatehy1,2, Abdelrahman Youssef3,4
1Department of Community Dentistry, Faculty of Dentistry, Mansoura University.
2Department of Preventive Dentistry, Faculty of Dentistry, Umm Al-Qura University, KSA,
3Department of Microbiology, Faculty of Medicine, Suez Canal University.
4Department of Basic and Clinical Oral Sciences, Faculty of Dentistry, Umm Al-Qura University, KSA.
Corresponding Author: Wahdan M. El-kwatehy
Background: Saliva is a complex oral fluid, can be used to monitor inflammatory diseases. Several salivary biomarkers may serve as an important biochemical parameter of gingival inflammation.
Objective: The aim of this study is to evaluate the concentration of salivary total protein, total antioxidant and a- defensin 1, 2 and 3 (HNP1-3) in relation to gingival condition of school children.
Methods: Unstimulated whole saliva was collected from 80 caries free school children, 40 children with healthy gingiva (control group) and 40 children with gingivitis to compare the salivary concentration of total protein, total antioxidant and a-defensin in both groups.
Results: The concentration of total protein, and a- defensin were highly significant in gingivitis compared to control group. However, the difference in total antioxidant between gingivitis and control groups was insignificant. Additionally, there were significant positive correlations between total protein versus both total antioxidant and a- defensin.
Conclusion: Children with gingival inflammation had high levels of total protein and a- defensin which may serve as an important biochemical parameter of gingival inflammation.
Key words:Gingival disease, Alpha defensin, Total protein, Total antioxidant.