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Original Research Article

Year: 2017 | Month: March | Volume: 7 | Issue: 3 | Pages: 143-149

Assessment of Salivary Immunoglobulin A, a-amylase, pH and Flow-rate Effects on Dental Caries Experience of Down’s Syndrome Children in Makkah, Saudi Arabia

Ohud S Alzughaibi1, Lujain A Filimban1, Abla A Arafa2

1BDS, General Dentist, Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia.
2Assistant Professor, Department of Pediatric Dentistry, Faculty of Dentistry, Misr International University, Egypt at sabbatical leave to Umm Al-Qura University, Makkah, Saudi Arabia.

Corresponding Author: Ohud S Alzughaibi


Objective: To assess the association between dental caries experience and salivary Immunoglobulin A, a-amylase, pH and flow-rate in Down’s syndrome children.
Materials and Methods: One-Hundred Down’s syndrome participants and one-hundred three healthy controls aged from 4 to15 years were examined to evaluate the caries experience using deft and DMFT. Unstimulated saliva was collected to assess the flow-rate, pH, sIgA and a-amylase. The total sIgA and a-amylase concentrations were measured using ELISA. Data analysis was performed using SPSS® v.20.0 software. Any p value ≤0.05 considered as significant.
Results: The deft of deciduous dentition presented significantly lower mean values in Down’s syndrome children compared to the control. While the DMFT index of permanent dentition presented significantly higher mean values in Down’s syndrome children compared to control group. Moreover, the salivary flow-rate and IgA were significantly higher in the Down’s syndrome children. While the Salivary pH and a-amylase showed significantly diminished mean values in Down’s syndrome compared to the controls.
Conclusion: In children with Down’s syndrome, the enhanced levels of salivary IgA, pH and flow-rate yielded a protective effect against dental caries.

Key words: Salivary factors, Dental health, Down’s Syndrome, sIgA.

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