Original Research Article
Year: 2017 | Month: February | Volume: 7 | Issue: 2 | Pages: 68-72
Study of Thyroid Function in Patients with Chronic Kidney Disease
Dr. J. Punekar1, Dr. A. A. Singh2, Dr. Manoj Kumar Malav3
1Associate Professor, 2Assistant Professor, 3Post Graduate Student,
Department of General Medicine, NSCB Medical College, Jabalpur.
Corresponding Author: Dr. Janki Punekar
ABSTRACT
Background: Thyroid dysfunction is a commonly seen endocrine abnormality among CKD patients. CKD has been known to affect the pituitary-thyroid axis and peripheral metabolism of thyroid hormones. This study was conducted to find out possible association of CKD and thyroid dysfunction and to estimate the occurrence of thyroid dysfunction in patients with chronic kidney disease and its correlation with severity of renal disease.
Materials and methods: A case control study was designed to study association of CKD cases and thyroid dysfunction. Total 75 CKD cases were recruited in case group and these cases were investigated, serum thyroid level measured by radioimmunoassay and their results were compared to a control group of 75 age/sex matched healthy subject.
Observations: Results of this study showed that majority of the cases were 30-59 years age group (48.21 +13.7). The male to female ratio in case group was 1.08:1 and in control group 1.02:1. Thyroid dysfunction was found to have 80% more occurrence in CKD Patients as compared to normal healthy controls. Most common thyroid dysfunction observed was overt hypothyroidism (42.66%) followed by Low T3 syndrome (21.33%), subclinical hypothyroidism (13.33%) and hyperthyroidism (2.7%). With the increasing severity of CKD, overt hypothyroidism also increased i.e. from 16.66% in stage-III, 38.8% in stage-IV to 47.06% in Stage-V. There was significant reduction of serum T3 level (69.58 ± 38.28ng/dl), T4 level (6.07± 2.55µg/dl) and elevation of TSH level (7.42± 4.25µIU/ml) in cases as compared to controls (p<0.001).
Conclusion: Thyroid dysfunction (overt hypothyroidism) showed a significant and strong correlation with CKD cases and various stage of CKD. Thus timely identification and treatment of these thyroid abnormalities could alter the course of the disease and help in reducing morbidity of CKD patients.
Key words: thyroid function, chronic kidney disease.