Original Research Article
Year: 2017 | Month: January | Volume: 7 | Issue: 1 | Pages: 115-123
Novel Diagnostic and Prognostic Immunological Markers for Chronic Periodontitis in Makkah Community
Ibtesam K. Afifi, Ebtehal A. Hamdy
Department of Basic & Clinical Oral Sciences, College of Dentistry, Umm Al-Qura University, KSA.
Corresponding Author: Ibtesam K. Afifi
ABSTRACT
The Aim: Investigating the role of Pentraxin-3 in comparison to tumor necrosis factor- α as a diagnostic and prognostic marker for chronic periodontitis.
Methods: Pentraxin-3 and tumor necrosis factor- α levels were measured by Enzyme-Linked Immunosorbent Assay for Gingival Crevicular Fluid samples of 53 chronic periodontitis patients before and after periodontal treatment as well as from 50periodontally healthy subjects as a control group. Differences between both groups regarding clinical parameters and tested biomarkers were assessed and correlations between them were calculated.
Results: The mean values of periodontal parameters were significantly reduced after treatment. Mean Pentraxin-3 and tumor necrosis factor- α levels were higher in chronic periodontitis patients than in the control group with a significant difference between both groups. Furthermore, these levels were reduced after treatment with a highly statistically significant difference. Positive correlations between the mean values of both markers levels, and clinical parameters were found whereas, Pentraxin-3 was more positively correlated.
Conclusion: As Pentraxin-3 is more positively correlated with clinical parameters of chronic periodontitis than tumor necrosis factor- α, it could be a better diagnostic and prognostic marker for the disease. However, further large-scale studies on both genders are recommended to confirm their role as prognostic markers.
Key words: Chronic Periodontitis, Gingival Crevicular Fluid, Inflammatory mediators, Pentraxin-3, Tumor necrosis factor- α.