Year: 2017 | Month: December | Volume: 7 | Issue: 12 | Pages: 256-275
Immune Dysfunction in Diabetes Mellitus (DM)
Vinod Kumar Rajana
Junior Research Fellow, Department of Biotechnology, IIT Guwahati
Diabetes mellitus patients are more prone to infection and also the wound healing capacity is very less. As the immune cells are well established mechanisms to protect us from pathogens. So, this article tried to combine all the recent updates of the relevant scientific data that have been done till now on “The effect of diabetes mellitus on the immune cells”. It has been well described that there is no or less effect of diabetes mellitus on the adaptive immune system. But if it comes to innate immune system diabetic mellitus affects the cellular functions like chemotaxis, phagocytosis, and killing of pathogens by monocytes, macrophages, and neutrophils. Most studies showed that decrease in normal cellular function, and alteration in enzyme activity and cytokine secretion in diabetic monocytes, macrophages, and neutrophils when compared to control cells. Improvement in cellular functions can be achieved by controlling diabetes mellitus. By understanding how the immune cells were altered in diabetes mellitus further we can proceed by targeting therapeutically to achieve better results in regulation of diabetic complication and improve the lifespan of diabetic patients.
Key words: Hyperglycemia, Insulin, Monocytes, Macrophages, Neutrophils, Advanced Glycation end product (AGE)