Original Research Article
Year: 2017 | Month: December | Volume: 7 | Issue: 12 | Pages: 207-211
Chromosomal Abnormalities and Primary Infertility
Anjali Shastry1, Preetha Tilak2, Amudha S1, Mary Margaret3, RainaJ4
1Tutor, 2Junior Consultant, 3Senior Lab Technician, 4Junior Lab Technician,
Division of Human Genetics, Department of Anatomy, St John’s Medical College, Bangalore
Corresponding Author: Anjali Shastry
Background: Primary infertility refers to the couples who are not able to achieve parenthood after one year of unprotected intercourse without using birth control measures. Chromosomal abnormalities are one of the important causes for primary infertility which requires proper diagnosis and genetic counseling.
Aim: To estimate numerical and structural chromosomal abnormalities in patients with primary infertility who were referred for karyotyping to Division of Human genetics, Department of Anatomy, St. John’s Medical College, Bangalore.
Materials and methods: A total of 203 patients with primary infertility were referred for karyotyping and counseling to Division of Human genetics, Department of Anatomy, St. Johns Medical College, Bangalore from January 2010 to June 2016. There were 117 male and 86 female patients and their age ranged from 20 to 40 years.
Chromosomal preparations were done using the peripheral lymphocyte culture method followed by GTG banding technique, automated photography and karyotyping.
Results: Out of 203 patients (117 males & 86 females) referred with history of primary infertility 36 showed chromosomal abnormalities out of which 17 had numerical abnormalities, 15 had structural abnormalities and 4 had both structural and numerical abnormalities.
Conclusion: We conclude that chromosomal analysis and possible genetic influences are important parameter in the assessment of cases with Primary infertility. The results influence the ultimate decision which needs to be considered before any procedure can be taken for preimplantation genetic diagnosis and assisted reproductive techniques.
Key words:Primary infertility, numerical abnormalities, structural abnormalities, pre implantation genetic diagnosis