Original Research Article
Year: 2017 | Month: October | Volume: 7 | Issue: 10 | Pages: 38-46
Effect and Association of ABO & Rh Incompatibility on Maternal Outcome
Mehar Preet Singh1, Dr. Kulbir Kaur2
1Research Scholar, Ph.D. - M.L.T (I.K GujralPunjab Technical University)
2Director Principal & Professor Pathology, Punjab Institute of Medical Sciences (PIMS), Jalandhar
Corresponding Author: Mehar Preet Singh
Background: Incompatibility affects those pregnancies in which maternal antibodies when cross the placental barrier and enters the fetal circulation, reacts and damage the fetal red cells, thus causing their premature destruction and results into HDN, Hydrops and even still birth.
Objective: To find the effect and association of incompatibility on maternal outcome.
Material and Methods: This was a prospective, observational study performed on 550 couples having female partners of 18 to 50 yrs. of age. ABO and Rh grouping was performed and compatibility was detected within each couple. The maternal record of couples was observed for fertility, reproductive outcome, live birth status, history of HDN and mortality of infants.
Results: The overall distribution of ABO & Rh among the compatible and incompatible group was not significantly different. Fertility, reproductive outcome, gender wise child birth and infant mortality were found independent with compatibility (p>0.050) but significant association was found with HDN (p=0.005), with gender of infant mortality (p=0.001). Compatible mating types were also found associated with gender of child birth and HDN (p<0.050).
Conclusion: It was concluded that incompatibility has no qualitative effect on the fertility, reproductive outcome and on infant mortality except HDN. But on the other hand, different mating types were found associated with gender of the born child, HDN and in some cases gender of the deceased infant. The data generated in this study will be useful for anticipatory management of the manifestations of incompatibility.
Key words: ABO & Rh Incompatibility, Fertility, Maternal Outcome, HDN, Infant mortality