International Journal of Health Sciences and Research

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Original Research Article

Year: 2017 | Month: October | Volume: 7 | Issue: 10 | Pages: 27-33

Role of Dexmedetomidine as Premedicant to Attenuate Pressor Response to Laryngoscopy and Intubation

Dr. Archana Vaidya1, Dr. Prasanna Phadke2

1Assist. Professor, 2Senior Resident,
Department of Anesthesia, Government Medical College, Nagpur, Maharashtra, India- 440001

Corresponding Author: Dr. Prasanna Phadke


Aims and Objectives: To study the efficacy of intravenous dexmedetomidine in the dose of1mcg/kg as a premedication for attenuation of pressor response to laryngoscopy for endotracheal intubation, and dose requirements of anesthetics for induction.
Method: Total 60 patients of either sex, ASA grade I, having age between 18-60 years, posted for elective surgery under general anaesthesia requiring endotracheal intubation were randomly allocated in two equal groups. Group A (Dexmedetomidine group)received Inj. dexmedetomidine 1 mcg/kg IV in 100ml of NS given over a period of 10 min in infusion form at constant rate prior to induction. Group B (placebo group) received 100ml of NS over a period of 10 min at constant rate prior to induction. All patients were monitored intra and postoperatively with respect to hemodynamic parameters, rate pressure product and any other side effects.
Results: Group A significantly attenuated the sympathetic response to laryngoscopy and tracheal intubation in terms of heart rate, systolic and diastolic blood pressure, mean arterial pressure and rate pressure product compared to group B. The total dose of propofol for induction of general anesthesia was significantly less in group A as compared to group B. In both the groups, no patient had bradycardia or hypotension.
Conclusion: Intravenous dexmedetomidine used as a premedication in a dose of 1 mcg/kg effectively blunted the pressor response to laryngoscopy and endotracheal intubation without any side effect.

Key words: Dexmedetomidine, Pressor Response, Laryngoscopy, Endotracheal Intubation

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