Original Research Article
Year: 2017 | Month: October | Volume: 7 | Issue: 10 | Pages: 93-96
Assessment of Liver Enzymes, Creatine Phosphokinase and Electrolytes in Patients with Hyperthyroidism Visiting Tertiary Center
Dr. Vijay K Sharma1, Dr. Vivek Pant1, Binod Aryal2, Suman Baral3
1MD Clinical Biochemistry, 2MSc Clinical Biochemistry, 3MD Internal Medicine,
Institute of medicine, Kathmandu, Nepal
Corresponding Author: Dr. Vijay K Sharma
Background: Thyroid hormones regulate the metabolisms of all cells. Hyperthyroidism is one of the most common endocrine disorders characterized by increased secretion of thyroid hormones T3 and/or T4. Since majority of metabolic activities occur in liver; kidney and muscle in body, so biochemical markers reflecting function of these organs are altered in hyperthyroid state. The present study is designed to compare the level of enzymes like Serum Glutamate Pyruvate Transferase (SGPT), Serum Glutamate Oxaloacetate Transferase (SGOT), Alkaline Phosphatase (ALP) and Creatine Phosphokinase (CPK) along with electrolytes (Sodium, Potassium) in clinically hyperthyroid patients with age and sex matched control subjects.
Materials and Methods: The Study was conducted in patients visiting to Endocrinology OPD in the Institute of Medicine, Nepal during the interval of 3rd February 2017 to 3rd May 2017. Total of fifty-one patients diagnosed as hyperthyroidism in age group 20-70 were included in the study. Patients with TSH values less than0.01 mIU/L were taken as cases. Total fifty-two individuals were taken as control in whom age and sex was matched.
Results: In hyperthyroid cases, the mean fT3 and fT4 values were 18.24 ± 9.33 pmol/L and 52.95 ± 20.81 pmol/L which were higher than that of controls. Similarly, mean TSH level in hyperthyroid patients was 0.03 ± 0.05 mIU/ml which was lower than that of control. The mean values of SGPT, SGOT, sodium and potassium in hyperthyroid cases were high compared to the mean values obtained from control. The mean value of ALP was significantly increased in cases whereas CPK was decreased compared to control.
Conclusion: It can be concluded from this study that increased value of SGPT, SGOT, ALP, sodium and potassium are seen in association with hyperthyroidism and conversely lower values of CPK are seen in association with hyperthyroidism. These altered parameters are seen in absence of underlying disease in individuals and are to be expected when analyzing serum sample of patients with hyperthyroidism.
Key words: Hyperthyroidism; Alkaline Phosphatase (ALP); Creatine Phosphokinase (CPK); Serum Glutamate Oxaloacetate Transferase (SGOT); Serum Glutamate Pyruvate Transferase (SGPT)