Original Research Article
Year: 2016 | Month: August | Volume: 6 | Issue: 8 | Pages: 334-338
Risk of Depression in Subjects with Type 2 Diabetes is Modulated by a Genetic Variant within DRD4 Gene: North Indian Diabetes-Depression Link Exploration Study (NIDDLES)
Gurpreet Kaur1, Harjot Dhillon1, Ritu Sharma1, Kanchan Mehta1, Shallu Khullar1, Sarabjit Mastana2, Monica Singh1, Puneetpal Singh1
1Department of Human Genetics, Punjabi University, Patiala.
2Human Genomics Lab., School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, United Kingdom.
Corresponding Author: Puneetpal Singh
The role and relevance of DRD4 gene SNPs for the risk of depression in type 2 diabetes remains to be clarified. To investigate its association, present cross sectional study was conducted on 399 type 2 diabetics who were diagnosed for depression using primary health care questionnaire-9 (PHQ-9) > 10 criteria. 191 subjects were depressed whereas, 208 subjects were found to be clinically non-depressed. Minor allele frequencies of two DRD4 SNPs rs1800955 and rs747302 were 0.45, 0.42 and 0.42, 0.34 in depressed and non depressed subjects respectively. C allele of rs747302 showed risk of depression (OR 1.41 95% CI 1.05- 1.87, P= 0.024) in comparison to G allele. It has been observed that carriers of CC genotype had approximately double the risk of depression (OR 1.96 95% CI 1.08- 3.56, P= 0.03) than GG carriers and this risk manifests in recessive mode.
Key words: Type 2 Diabetes, Depression, DRD4 gene polymorphism, Punjab.