Original Research Article
Year: 2015 | Month: August | Volume: 5 | Issue: 8 | Pages: 284-288
Assessment of Serum Adiponectin and Lipid Parameters in Patients of Acute Myocardial Infarction
Kumud N Harley1, Kanchan Mohod2, Jayshri Jankar3, Satish Kumar4
1Associate Professor, 2Assistant Professor, 3PG Student, 4Professor,
Dept. of Biochemistry, Mahatma Gandhi Institute of Medical Sciences Sevagram, Mahatashtra.
Corresponding Author: Satish Kumar
Background: Several studies have been carried out to evaluate the plasma Adiponectin levels and its associations with chronic heart disease. However, limited data is available regarding the serum Adiponectin levels and the Acute Myocardial infarction (AMI) especially in central India.
Material and Methods: The present cross sectional study was conducted at tertiary care hospital in central India. Study groups comprised of 101 AMI cases and 100 age and sex matched apparently healthy controls to assess the status of serum Adiponectin and lipid parameters.
Observations: We have observed significantly low serum Adiponectin levels in AMI patients as compared to controls with P value 0.0001. In addition, when compared with lipid parameters, Adiponectin levels were positively related with high density lipoprotein cholesterol, whereas, negatively correlate with the serum triglycerides, Total Cholesterol and Low density lipoprotein Cholesterol. In addition when compared lipid parameters between controls and cases, significantly increased Serum triglycerides (P=0.0001) and Total Cholesterol (P=0.001) and low density lipoprotein cholesterol (P=0.0001) and significantly low serum High density lipoprotein Cholesterol with P=0.0001 were observed respectively in acute myocardial infarction cases as compared to Controls.
Conclusion: low serum Adiponectin may be considered as a risk factor for a development of atherogenesis and eventually for Acute Myocardial Infarction.
Key words: Serum Adiponectin, Lipid Parameters, Acute Myocardial Infarction.