Original Research Article
Year: 2014 | Month: September | Volume: 4 | Issue: 9 | Pages: 277-281
Distribution of ABO and Rh (D) Allele Frequencies in the Type 1 Diabetes Mellitus Patients and Healthy Individuals
Shikha Jaggi1, Abhay Singh Yadav2
1Junior Research Fellow, 2Professor, Human Genetics Laboratory, Department of Zoology, Kurukshetra University, Kurukshetra- 136119, Haryana, India.
Corresponding Author: Shikha Jaggi
Aim: To compare the distribution of serological traits like ABO and Rh (D) blood groups among type 1 diabetes mellitus (T1DM) patients and control subjects.
Objective: Comparative analysis of ABO & Rh blood group phenotype and allele frequencies in T1DM and healthy individuals.
Materials & Methods: A total of 98 individuals (40 T1DM and 58 controls) were evaluated. Blood samples were analyzed for ABO and Rh (D) blood groups and allele frequencies were calculated using chi-square test.
Result: Data of the present study revealed that frequency of O allele (0.500) was highest among T1DM patients followed by B allele (0.311) and A allele (0.109). Chi-square value for ABO blood group was found to be significant (p<0.05) in controls while it was non-significant (p>0.05) in T1DM patients. D allele was more frequent in controls (0.679) than T1DM patients (0.644).
Conclusion: The findings of the present study suggest that there is no association between distributions of ABO blood types in T1DM.
Key words: Type 1 diabetes mellitus, ABO blood group, Rh (D) blood group, allele frequency.