Year: 2025 | Month: February | Volume: 15 | Issue: 2 | Pages: 261-265
DOI: https://doi.org/10.52403/ijhsr.20250234
Primary Malignant Melanoma of the Vagina: A Rare Case Report
Dr. Veena Gupta1, Dr. Sahil Goel2, Dr. Anjali Ahalawat3, Dr. Sumiti Gupta4, Dr. Sunita Singh5
1Professor, Department of Pathology, Pt. B. D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
2Junior Resident, Department of Pathology, Pt. B. D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
3Senior Resident, Department of Pathology, Pt. B. D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
4Professor, Department of Pathology, Pt. B. D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
5Senior Professor and Head, Department of Pathology, Pt. B. D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
Corresponding Author: Dr. Sahil Goel
ABSTRACT
Primary malignant melanoma of the vagina (PMMV) is an exceptionally rare form of cancer, accounting for only 3% of melanomas in the female genital tract and 0.3%–0.8% of all melanomas in females. Vaginal melanoma is a highly aggressive malignancy with a poor prognosis, as evidenced by a 5-year survival rate ranging from 5% to 25%. The high recurrence rates, regional lymph node involvement, and distant metastases contribute to its unfavourable outcomes. The amelanotic form of vaginal melanoma can often be misdiagnosed as other primary vaginal malignancies, which may have better prognoses. Early detection and treatment are crucial for improving survival chances despite the generally poor prognosis. We report a case of 70 year old female presenting with friable mass in vaginal vault which was diagnosed as amelanotic melanoma on biopsy.
Key words: Primary malignant melanoma of the vagina, PMMV, malignant melanoma, melanoma