Year: 2025 | Month: February | Volume: 15 | Issue: 2 | Pages: 189-193
DOI: https://doi.org/10.52403/ijhsr.20250225
The Interplay Between Antibiotics and Probiotics: Implications on Gut Health and Antibiotic Efficacy
Ushika Bhattacharjee1, Shradha Parvathy Joy2, Aruna Rajeswari Balaprakash Bhavani3, Vinay Seetharaman4
1Department of Medicine, Faculty of Medicine, Tbilisi State Medical University, Georgia
2Department of Medicine, Faculty of Medicine, Tbilisi State Medical University, Georgia.
3Department of Medicine, Faculty of Medicine, Tbilisi State Medical University, Georgia
4University of Georgia School of Health Sciences, Georgia.
Corresponding Author: Ushika Bhattacharjee
ABSTRACT
Patients undergoing antibiotic treatment are susceptible to antibiotic-associated diarrhea (AAD), which can lead to complications such as dehydration and longer hospital stays. Research indicates that probiotics can significantly reduce the incidence of C. difficile-associated diarrhea by up to 66%. These beneficial microorganisms help restore gut flora balance and enhance the intestinal barrier, making them effective in preventing and treating AAD in both children and adults. Probiotics exert their effects by modulating the immune response and inhibiting pathogen adhesion. Although numerous studies highlight the efficacy of various probiotic strains in managing infections, further standardized clinical trials are essential to validate these results and optimize treatment protocols.
Key words: AAD, Antibiotic, Probiotic, C. difficile, Gut flora