Year: 2025 | Month: February | Volume: 15 | Issue: 2 | Pages: 136-144
DOI: https://doi.org/10.52403/ijhsr.20250218
Non-Surgical Healing of Large Endodontic Lesions Using a Novel Combination of Triple Antibiotics: A Report of 2 Cases
Dr. Karishma A Krishnani1, Dr. Shreema Shetty2
1Department of Conservative Dentistry and Endodontics, 2Reader, Department of Conservative Dentistry and Endodontics, A J Institute of Dental Sciences, Mangalore, India.
Corresponding Author: Dr. Karishma A Krishnani
ABSTRACT
Background: Infections of the root canal system are typically polymicrobial. Due to their complexity, no single antibiotic can effectively sterilize the canal. Microorganisms re-accessing the pulp chamber or radicular space can cause primary or secondary infections, leading to endodontic pathosis. To avoid complications associated with surgical treatment of large endodontic lesions, conservative non-surgical approaches are recommended.
Aim: This report aims to describe the healing of symptomatic large endodontic lesions through non-surgical management using a novel combination of triple antibiotics
Methods and Material: Two cases of symptomatic large endodontic lesions were treated non-surgically with a novel combination of triple antibiotics. The approach focused on the disinfection of the root canal system to eliminate active intracanal microorganisms.
Statistical Analysis: Follow-up radiographs were utilized to qualitatively assess the progressive healing of the endodontic lesions.
Results: Follow-up radiographs of both cases showed progressive healing of the endodontic lesions. These findings suggest that surgical treatment is not always necessary for managing symptomatic large endodontic lesions.
Conclusions: Even cyst-like periapical lesions can heal following conservative endodontic therapy with a novel combination of triple antibiotics, effectively eliminating active intracanal microorganisms through root canal system disinfection.
Key words: Polymicrobial infection, Triple antibiotics, Non-surgical management, Endodontic lesions, Disinfection