Year: 2025 | Month: January | Volume: 15 | Issue: 1 | Pages: 280-287
DOI: https://doi.org/10.52403/ijhsr.20250137
Correlations between Oxidative Stress and Thyroid Hormone in Subclinical and Overt Hyperthyroid Patients of Nepal
Fuleshwar Mandal1, Dr. Mohd Babu Khan2
1PhD Scholar, School of Life and Allied Health Sciences, Glocal University Mirzapur Pole, Saharanpur, Uttar Pradesh, India
2Assistant Professor, Glocal School of Life and Natural Sciences, Glocal University Mirzapur Pole, Saharanpur, Uttar Pradesh, India.
Corresponding Author: Dr. Mohd Babu Khan
ABSTRACT
Aim: The main aim of the present study was to correlate the oxidative stress marker with thyroid hormone in subclinical and overt hyperthyroid patients of Nepal which remains unexplored till June 2024.
Methods: A total of 129 patients with hyperthyroidism including subclinical and overt cases were enrolled in this cross-sectional study. Thyroid function parameter (T3, T4, and TSH) and oxidative stress marker including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase activity and total antioxidant capacity (TAC) in patient were estimated using Chemiluminescent immunoassay and spectrophotometrically, respectively. Utilizing IBM SPSS version 20.0., Chi-square test and Pearson's correlation coefficient were employed for statistical analysis.
Results: Significantly higher level of T3 and T4 were found in overt case when compared subclinical case of hyperthyroidism. In correlation analysis, T3 showed significant positive correlation with MDA (r: 0.487, p < 0.01) and SOD (r: 0.623, p < 0.01), while significant negative correlation with GPx (r: -0. 834, p < 0.01) and TAC (r: -0.672, p < 0.01). Similarly, T4 also showed significant positive correlation with MDA (r: 0.438, p < 0.01) and SOD (r: 0.559, p < 0.01), while significant negative correlation with GPx (r: -0.745, p < 0.01) and TAC (r: -0.605, p < 0.01). Unlike, TSH showed significant negative correlation with MDA (r: -0.491, p < 0.01) and SOD (r: -0. 487, p < 0.01), and significant positive correlation with GPx (r: 0.645, p < 0.01), GR (r: 0.281, p< 0.01) and TAC (r: 0.888, p < 0.01). Similar trends of correlations with strong to extreme magnitude between thyroid hormone and stress markers was observed in overt case compared to subclinical case of hyperthyroidism.
Conclusion: oxidative stress amplifies the thyroid hormones highlighting the importance of adjuvant antioxidant in treatment of hyperthyroidism.
Key words: Oxidative stress, Antioxidant enzyme system, Thyroid hormones, Hyperthyroidism